Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Sep 9;16(1):111.
doi: 10.1186/s12876-016-0505-5.

Surgical treatment and prognosis of gastric neuroendocrine neoplasms: a single-center experience

Chaoyong Shen  1 , Huijiao Chen  2 , Haining Chen  1 , Yuan Yin  1 , Luyin Han  3 , Jiaju Chen  1 , Sumin Tang  1 , Xiaonan Yin  1 , Zongguang Zhou  4 , Bo Zhang  5 , Zhixin Chen  1
Affiliations

Surgical treatment and prognosis of gastric neuroendocrine neoplasms: a single-center experience

Chaoyong Shen et al. BMC Gastroenterol. .

Abstract

Background: Gastric neuroendocrine neoplasms (G-NENs) are uncommon, and data on their management is limited. We here investigated the clinicopathological characteristics, surgical and survival outcomes in G-NENs among Chinese. Moreover, we will discuss their prognostic value.

Methods: From existing databases of the West China Hospital, we retrospectively identified 135 consecutive patients who were surgically treated and pathologically diagnosed as G-NENs from January 2009 to August 2015.

Results: This entire cohort comprised 98 males and 37 females, with a median age of 60 years. Twenty-five patients underwent endoscopic resection, while 110 patients underwent open/laparoscopic surgery. Thirty-nine patients had neuroendocrine tumor G1 (NET G1), seven patients had neuroendocrine tumor G2 (NET G2), 69 patients had neuroendocrine carcinoma G3 (NEC G3) and 20 patients had mixed adenoneuroendocrine carcinoma (MANEC). The median survival was not achieved for both NET G1 and NET G2 versus 19 months (range 3-48) for NEC G3 and 10.5 months (range 3-45) for MANEC. The 3-year survival rates for stage I, II, III, and IV were 91.1 %, 78.6 %, 51.1 % and 11.8 %, respectively (P < 0.001). As for the prognostic analysis, both surgical margin and the newly updated World Health Organization (WHO) classification were independent predictors of overall survival (OS).

Conclusions: G-NENs are a kind of rare tumors, and patients with NET G3 and MANEC have unfavorable prognosis even surgically treated. Moreover, surgical margin and the new 2010 WHO criteria are closely associated with OS for G-NENs.

Keywords: Neuroendocrine neoplasms; New WHO grading; Prognosis; Stomach; Surgery.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Overall survival of 114 G-NENs patients after radical resection (stratified by the new 2010 WHO classification). The NET G1 showed significant better OS compared with that of NEC G3 and MANEC (P < 0.001, and P < 0.001, respectively), but did not differ between NET G1 and NET G2 (P = 0.162), as well as those between NEC G3 and MANEC (P = 0.102)
Fig. 2
Fig. 2
Comparison of overall survival in all patients with G-NENs of different TNM stages. The subgroups of patients with stage I and II obtained better OS than those in stage III and IV, respectively (I vs III, P < 0.001; I vs IV, P < 0.001; II vs III, P = 0.036; II vs IV, P < 0.001), as well as that between stage III and IV (P < 0.001), while no notable differences were found between stage I and II (P = 0.692)
Fig. 3
Fig. 3
Comparison of survival in all patients with G-NENs of different surgical margins
See this image and copyright information in PMC

References

    1. La Rosa S, Inzani F, Vanoli A, Klersy C, Dainese L, Rindi G, et al. Histologic characterization and improved prognostic evaluation of 209 gastric neuroendocrine neoplasms. Hum Pathol. 2011;42:1373–1384. doi: 10.1016/j.humpath.2011.01.018. - DOI - PubMed
    1. La Rosa S, Vanoli A. Gastric neuroendocrine neoplasms and related precursor lesions. J Clin Pathol. 2014;67:938–948. doi: 10.1136/jclinpath-2014-202515. - DOI - PubMed
    1. Modlin IM, Lye KD, Kidd M. Carcinoid tumors of the stomach. Surg Oncol. 2003;12:153–172. doi: 10.1016/S0960-7404(03)00034-3. - DOI - PubMed
    1. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, et al. One hundred years after “carcinoid” epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008;26:3063–3072. doi: 10.1200/JCO.2007.15.4377. - DOI - PubMed
    1. Jung HJ, Hong SJ, Han JP, Kim HS, Jeong GA, Cho GS, et al. Long-term outcome of endoscopic and surgical resection for foregut neuroendocrine tumors. J Dig Dis. 2015 - PubMed