Prekallikrein deficiency in a 15-year-old boy with Ménière's disease: a case report
- PMID: 27615147
- DOI: 10.1080/17843286.2016.1227907
Prekallikrein deficiency in a 15-year-old boy with Ménière's disease: a case report
Abstract
Congenital prekallikrein deficiency is a rare disorder in which there is an in vitro clotting defect despite absence of bleeding or thrombotic tendency. In this report, a 15-year-old boy with an unexpected markedly prolonged activated partial thrombin time, a normal prothrombin time, and without personal nor familial history of bleeding or thrombosis is presented. Laboratory investigation revealed a severe prekallikrein deficiency. This case highlights the importance of following a diagnostic algorithm to establish the correct diagnosis. Moreover, by selecting appropriate laboratory tests, unnecessary and repeatedly testing can be avoided.
Keywords: Prekallikrein deficiency; Prolonged aPTT.
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