Melanoma central nervous system metastases: current approaches, challenges, and opportunities

Justine V Cohen¹, Hussain Tawbi², Kim A Margolin³, Ravi Amravadi⁴, Marcus Bosenberg¹, Priscilla K Brastianos⁵, Veronica L Chiang¹, John de Groot⁶, Isabella C Glitza², Meenhard Herlyn⁷, Sheri L Holmen⁸, Lucia B Jilaveanu¹, Andrew Lassman⁹, Stergios Moschos¹⁰, Michael A Postow¹¹, Reena Thomas¹², John A Tsiouris¹³, Patrick Wen¹⁴, Richard M White¹⁵, Timothy Turnham¹⁶, Michael A Davies², Harriet M Kluger¹

Affiliations

¹ Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
² Department of Melanoma, Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Department of Medical Oncology & Therapeutics Research, City of Hope Cancer Center, Duarte, CA, USA.
⁴ Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
⁵ Division of Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA.
⁶ Division of Neuro-Oncology, MD Anderson Cancer Center, Houston, TX, USA.
⁷ Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
⁸ Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
⁹ Department of Neurology & Herbert Irving Comprehensive, Cancer Center, Columbia University Medical Center, New York, NY, USA.
¹⁰ UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹¹ Department of Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
¹² Division of Neuro-Oncology, Department of Neurology, Stanford University, Stanford, CA, USA.
¹³ Department of Radiology, New York-Presbyterian Hospital - Weill Cornell Medicine, New York, NY, USA.
¹⁴ Department of Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
¹⁵ Department of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
¹⁶ Melanoma Research Foundation, Washington, DC, USA.

PMID: 27615400
PMCID: PMC5398760
DOI: 10.1111/pcmr.12538

Review

Melanoma central nervous system metastases: current approaches, challenges, and opportunities

Justine V Cohen et al. Pigment Cell Melanoma Res. 2016 Nov.

. 2016 Nov;29(6):627-642.

doi: 10.1111/pcmr.12538. Epub 2016 Oct 22.

Authors

Affiliations

¹ Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
² Department of Melanoma, Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Department of Medical Oncology & Therapeutics Research, City of Hope Cancer Center, Duarte, CA, USA.
⁴ Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
⁵ Division of Neuro-Oncology, Massachusetts General Hospital, Boston, MA, USA.
⁶ Division of Neuro-Oncology, MD Anderson Cancer Center, Houston, TX, USA.
⁷ Melanoma Research Center, The Wistar Institute, Philadelphia, PA, USA.
⁸ Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
⁹ Department of Neurology & Herbert Irving Comprehensive, Cancer Center, Columbia University Medical Center, New York, NY, USA.
¹⁰ UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
¹¹ Department of Oncology, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
¹² Division of Neuro-Oncology, Department of Neurology, Stanford University, Stanford, CA, USA.
¹³ Department of Radiology, New York-Presbyterian Hospital - Weill Cornell Medicine, New York, NY, USA.
¹⁴ Department of Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
¹⁵ Department of Cancer Biology & Genetics, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
¹⁶ Melanoma Research Foundation, Washington, DC, USA.

PMID: 27615400
PMCID: PMC5398760
DOI: 10.1111/pcmr.12538

Abstract

Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.

Keywords: brain metastasis; clinical trials; experimental models; leptomeningeal disease; tumor microenvironment.

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References

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Melanoma central nervous system metastases: current approaches, challenges, and opportunities

Affiliations

Melanoma central nervous system metastases: current approaches, challenges, and opportunities

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

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Medical