A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop¹, Heather Thorne^{1

2}, Shahneen Sandhu³, Anne Hamilton^{3

4

5}, Christopher Mintoff⁶, Elizabeth Christie^{1

7}, Odette Spruyt^{5

8}, Scott Williams⁹, Orla McNally^{4

10}, Linda Mileshkin^{3

7}, Sumitra Ananda^{3

4}, Julene Hallo⁴, Sherene Loi^{3

7

11}, Clare Scott¹², Peter Savas^{3

11}, Lisa Devereux⁷, Patricia O'Brien¹³, Sameera Gunawardena¹³, Clare Hampson¹³, Kate Strachan¹³, Rufaro Diana Jaravaza¹³, Victoria Francis¹³, Gregory Young¹³, David Ranson¹³, Ravindra Samaranayake¹³, David Stevens¹⁴, Samantha Boyle⁶, Clare Fedele^{6

7

15}, Monique Topp¹², Gwo Ho¹², Zhi Ling Teo^{7

11}, Renea A Taylor¹⁶, Melissa M Papargiris¹⁷, Mitchell G Lawrence¹⁷, Hong Wang¹⁷, Gail P Risbridger¹⁷, Nicole M Haynes^{7

18}, Mikolaj Medon^{18

19}, Ricky W Johnstone^{7

18}, Eva Vidacs¹⁸, Gisela Mir Arnau²⁰, Ismael A Vergara^{12

21}, Anthony T Papenfuss^{7

18

21}, Grant McArthur^{3

7}, Paul Waring¹⁵, Shirley Carvosso²², Christopher Angel²³, David Gyorki^{19

24}, Benjamin Solomon^{3

7}, Gillian Mitchell^{7

25

26}, Sue Shanley²⁵, Prudence A Francis³, Sarah-Jane Dawson^{3

7

27}, Amy Haffenden²⁸, Erin Tidball²⁸, Mila Volchek²⁹, Jan Pyman²⁹, Mohammed Madadin^{13

30}, Jodie Leditschke^{13

31}, Stephen Cordner^{13

31}; Melbourne Melanoma Project; Australian Ovarian Cancer Study Group (AOCS); Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab); Mark Shackleton^{3

6

7}, David D Bowtell^{1

7

32}

Affiliations

¹ Cancer Genomics Program, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
² kConFab, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
³ Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁴ Department of Oncology, the Royal Women's Hospital, Parkville, Victoria, Australia.
⁵ Department of Medicine, Dentistry and Health Sciences, the University of Melbourne, Parkville, Victoria, Australia.
⁶ Cancer Development and Treatment Laboratory, Research Department, Peter MacCallum Cancer, Melbourne, Victoria, Australia.
⁷ Sir Peter MacCallum Department of Oncology, the University of Melbourne, Victoria, Australia.
⁸ Department of Pain and Palliative Care, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁹ Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹⁰ Department of Obstetrics and Gynaecology, the University of Melbourne, Parkville, Victoria, Australia.
¹¹ Translational Breast Cancer Genomics and Therapeutics Laboratory, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹² The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
¹³ The Victorian Institute of Forensic Medicine, Southbank, Victoria, Australia.
¹⁴ Tobin Brothers Funerals, Victoria, Australia.
¹⁵ Department of Pathology, the University of Melbourne, Parkville, Victoria, Australia.
¹⁶ Department of Physiology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Clayton, Victoria, Australia.
¹⁷ Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Clayton, Victoria, Australia.
¹⁸ Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹⁹ Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁰ Molecular Genomics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²¹ Bioinformatics and Cancer Genomics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²² The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²³ Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁴ The Department of Surgery, the University of Melbourne, Parkville, Victoria, Australia.
²⁵ The Jack Brockhoff Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁶ Hereditary Cancer Program, BC Cancer Agency, Vancouver, Canada.
²⁷ Molecular Biomarkers and Translational Genomics Laboratory, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁸ Department of Nursing, the Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁹ Department of Pathology, the Royal Women's Hospital, Parkville, Victoria, Australia.
³⁰ Department of Pathology, University of Dammam, Dammam, Saudi Arabia.
³¹ Department of Forensic Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
³² The Garvan Institute, Sydney, New South Wales, Australia.

PMID: 27617737
DOI: 10.1038/nbt.3674

A community-based model of rapid autopsy in end-stage cancer patients

Kathryn Alsop et al. Nat Biotechnol. 2016 Oct.

. 2016 Oct;34(10):1010-1014.

doi: 10.1038/nbt.3674. Epub 2016 Sep 12.

Authors

Affiliations

¹ Cancer Genomics Program, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
² kConFab, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
³ Division of Cancer Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁴ Department of Oncology, the Royal Women's Hospital, Parkville, Victoria, Australia.
⁵ Department of Medicine, Dentistry and Health Sciences, the University of Melbourne, Parkville, Victoria, Australia.
⁶ Cancer Development and Treatment Laboratory, Research Department, Peter MacCallum Cancer, Melbourne, Victoria, Australia.
⁷ Sir Peter MacCallum Department of Oncology, the University of Melbourne, Victoria, Australia.
⁸ Department of Pain and Palliative Care, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁹ Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹⁰ Department of Obstetrics and Gynaecology, the University of Melbourne, Parkville, Victoria, Australia.
¹¹ Translational Breast Cancer Genomics and Therapeutics Laboratory, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹² The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
¹³ The Victorian Institute of Forensic Medicine, Southbank, Victoria, Australia.
¹⁴ Tobin Brothers Funerals, Victoria, Australia.
¹⁵ Department of Pathology, the University of Melbourne, Parkville, Victoria, Australia.
¹⁶ Department of Physiology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Clayton, Victoria, Australia.
¹⁷ Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash Partners Comprehensive Cancer Consortium, Monash University, Clayton, Victoria, Australia.
¹⁸ Cancer Therapeutics Program, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹⁹ Division of Surgical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁰ Molecular Genomics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²¹ Bioinformatics and Cancer Genomics, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²² The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²³ Department of Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁴ The Department of Surgery, the University of Melbourne, Parkville, Victoria, Australia.
²⁵ The Jack Brockhoff Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁶ Hereditary Cancer Program, BC Cancer Agency, Vancouver, Canada.
²⁷ Molecular Biomarkers and Translational Genomics Laboratory, Research Department, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁸ Department of Nursing, the Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
²⁹ Department of Pathology, the Royal Women's Hospital, Parkville, Victoria, Australia.
³⁰ Department of Pathology, University of Dammam, Dammam, Saudi Arabia.
³¹ Department of Forensic Medicine, School of Public Health and Preventive Medicine, Monash University, Victoria, Australia.
³² The Garvan Institute, Sydney, New South Wales, Australia.

PMID: 27617737
DOI: 10.1038/nbt.3674

No abstract available

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References

1. Nature. 2015 Feb 19;518(7539):422-6 - PubMed
1. Endocrinology. 1995 Jan;136(1):164-71 - PubMed
1. Nature. 2010 Oct 28;467(7319):1109-13 - PubMed
1. Blood. 2012 Aug 2;120(5):1067-76 - PubMed
1. Cancer Res. 2015 Aug 1;75(15):2963-8 - PubMed

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A community-based model of rapid autopsy in end-stage cancer patients

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A community-based model of rapid autopsy in end-stage cancer patients

Authors

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References

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LinkOut - more resources

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