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Review
. 2016 Sep 7;7(9):61.
doi: 10.3390/genes7090061.

Telomerase Activation in Hematological Malignancies

Joana Ropio  1   2   3   4 , Jean-Philippe Merlio  5   6 , Paula Soares  7   8   9 , Edith Chevret  10
Affiliations
Review

Telomerase Activation in Hematological Malignancies

Joana Ropio et al. Genes (Basel). .

Abstract

Telomerase expression and telomere maintenance are critical for cell proliferation and survival, and they play important roles in development and cancer, including hematological malignancies. Transcriptional regulation of the rate-limiting subunit of human telomerase reverse transcriptase gen (hTERT) is a complex process, and unveiling the mechanisms behind its reactivation is an important step for the development of diagnostic and therapeutic applications. Here, we review the main mechanisms of telomerase activation and the associated hematologic malignancies.

Keywords: amplification; epigenetic; hematological malignancy; mutation; polymorphism; telomerase activity; virus.

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Conflict of interest statement

The authors declare no conflict of interest.

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