Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct;13(5):377-8.
doi: 10.1089/zeb.2016.1370.

Mixtures, Metabolites, and Mechanisms: Understanding Toxicology Using Zebrafish

Joshua T Gamse  1 , Daniel A Gorelick  2
Affiliations

Mixtures, Metabolites, and Mechanisms: Understanding Toxicology Using Zebrafish

Joshua T Gamse et al. Zebrafish. 2016 Oct.

Abstract

For more than 60 years, zebrafish have been used in toxicological studies. Due to their transparency, genetic tractability, and compatibility with high-throughput screens, zebrafish embryos are uniquely suited to study the effects of pharmaceuticals and environmental insults on embryonic development, organ formation and function, and reproductive success. This special issue of Zebrafish highlights the ways zebrafish are used to investigate the toxic effects of endocrine disruptors, pesticides, and heavy metals.

PubMed Disclaimer

Conflict of interest statement

Statement No competing financial interests exist.

References

    1. Haffter P, Granato M, Brand M, Mullins MC, Hammerschmidt M, Kane DA, et al. . The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development 1996;123:1–36 - PubMed
    1. Driever W, Solnica-Krezel L, Schier AF, Neuhauss SC, Malicki J, Stemple DL, et al. . A genetic screen for mutations affecting embryogenesis in zebrafish. Development 1996;123:37–46 - PubMed
    1. Battle HI, Hisaoka KK. Effects of ethyl carbamate (urethan) on the early development of the teleost Brachydanio rerio. Cancer Res 1952;12:334–340 - PubMed
    1. Jones RW, Huffman MN. Fish embryos as bio-assay material in testing chemicals for effects on cell division and differentiation. Trans Am Microsc Soc 1957;76:177–183
    1. Padilla S, Corum D, Padnos B, Hunter DL, Beam A, Houck KA, et al. . Zebrafish developmental screening of the ToxCast Phase I chemical library. Reprod Toxicol 2012;33:174–187 - PubMed

Publication types

Substances

LinkOut - more resources