Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Apr;114(4):717-739.
doi: 10.1002/bit.26182. Epub 2016 Oct 5.

Management of knee osteoarthritis. Current status and future trends

Marta Ondrésik  1   2 , Fatima R Azevedo Maia  1   2 , Alain da Silva Morais  1   2   3 , Ana C Gertrudes  1   2   3 , Ana H Dias Bacelar  1   2   3 , Cristina Correia  1   2   3 , Cristiana Gonçalves  1   2   3 , Hajer Radhouani  1   2   3 , Rui Amandi Sousa  1   2   3 , Joaquim M Oliveira  1   2 , Rui L Reis  1   2
Affiliations
Review

Management of knee osteoarthritis. Current status and future trends

Marta Ondrésik et al. Biotechnol Bioeng. 2017 Apr.

Abstract

Osteoarthritis (OA) affects a large number of the population, and its incidence is showing a growing trend with the increasing life span. OA is the most prevalent joint condition worldwide, and currently, there is no functional cure for it. This review seeks to briefly overview the management of knee OA concerning standardized pharmaceutical and clinical approaches, as well as the new biotechnological horizons of OA treatment. The potential of biomaterials and state of the art of advanced therapeutic approaches, such as cell and gene therapy focused primarily on cartilage regeneration are the main subjects of this review. Biotechnol. Bioeng. 2017;114: 717-739. © 2016 Wiley Periodicals, Inc.

Keywords: articular cartilage; biomaterials; gene therapy; osteoarthritis; regeneration; scaffolds; tissue engineering; viscosupplementation.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources