Beta-blockers in septic shock: a magnifying glass on the relation heart vessel

Affiliations

Comment

Calypso Mathieu et al. J Thorac Dis. 2016 Aug.

. 2016 Aug;8(8):E802-4.

doi: 10.21037/jtd.2016.07.12.

¹ Service d'anesthésie et de réanimation, Hôpital Nord, Assistance Publique Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.

No abstract available

Conflict of interest statement

The authors have no conflicts of interest to declare.

Esmolol in septic shock: old pathophysiological concepts, an old drug, perhaps a new hemodynamic strategy in the right patient.
Morelli A, Sanfilippo F, Romano SM. Morelli A, et al. J Thorac Dis. 2016 Nov;8(11):3059-3062. doi: 10.21037/jtd.2016.11.111. J Thorac Dis. 2016. PMID: 28066583 Free PMC article. No abstract available.

Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study.
Morelli A, Singer M, Ranieri VM, D'Egidio A, Mascia L, Orecchioni A, Piscioneri F, Guarracino F, Greco E, Peruzzi M, Biondi-Zoccai G, Frati G, Romano SM. Morelli A, et al. Intensive Care Med. 2016 Oct;42(10):1528-1534. doi: 10.1007/s00134-016-4351-2. Epub 2016 Apr 21. Intensive Care Med. 2016. PMID: 27101380

1. Leone M, Asfar P, Radermacher P, et al. Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature. Crit Care 2015;19:101. 10.1186/s13054-015-0794-z - DOI - PMC - PubMed
1. Spink WW, Reddin J, Zak SJ, et al. Correlation of plasma catecholamine levels with hemodynamic changes in canine endotoxin shock. J Clin Invest 1966;45:78-85. 10.1172/JCI105325 - DOI - PMC - PubMed
1. Dünser MW, Hasibeder WR. Sympathetic overstimulation during critical illness: adverse effects of adrenergic stress. J Intensive Care Med 2009;24:293-316. 10.1177/0885066609340519 - DOI - PubMed
1. Kimmoun A, Louis H, Al Kattani N, et al. β1-adrenergic inhibition improves cardiac and vascular function in experimental septic shock. Crit Care Med 2015;43:e332-40. 10.1097/CCM.0000000000001078 - DOI - PubMed
1. Aboab J, Sebille V, Jourdain M, et al. Effects of esmolol on systemic and pulmonary hemodynamics and on oxygenation in pigs with hypodynamic endotoxin shock. Intensive Care Med 2011;37:1344-51. 10.1007/s00134-011-2236-y - DOI - PubMed