Heart rate reduction may be a major determinant of vascular tone in esmolol-treated septic shock patients-although still remains to be confirmed!
- PMID: 27619799
- PMCID: PMC4999694
- DOI: 10.21037/jtd.2016.07.66
Heart rate reduction may be a major determinant of vascular tone in esmolol-treated septic shock patients-although still remains to be confirmed!
Conflict of interest statement
Antoine Kimmoun and Bruno Levy received a grant from Baxter for the Esmosepsis study (NCT02068287) and fees for consulting activity (Baxter and MSD). The other authors have no conflicts of interest to declare.
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Comment in
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Esmolol in septic shock: old pathophysiological concepts, an old drug, perhaps a new hemodynamic strategy in the right patient.J Thorac Dis. 2016 Nov;8(11):3059-3062. doi: 10.21037/jtd.2016.11.111. J Thorac Dis. 2016. PMID: 28066583 Free PMC article. No abstract available.
Comment on
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Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study.Intensive Care Med. 2016 Oct;42(10):1528-1534. doi: 10.1007/s00134-016-4351-2. Epub 2016 Apr 21. Intensive Care Med. 2016. PMID: 27101380
References
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- Karim F, Poucher SM. Beta-adrenoceptors in vascular capacitance responses to unloading of carotid baroreceptors in anesthetized dogs. Am J Physiol 1997;273:H1713-8. - PubMed
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