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Comment
. 2016 Aug;8(8):E827-8.
doi: 10.21037/jtd.2016.07.58.

The evolution of mitral valve prolapse: insights from the Framingham Heart Study

Zhaozhuo Niu  1 , Vincent Chan  2 , Thierry Mesana  2 , Marc Ruel  2
Affiliations
Comment

The evolution of mitral valve prolapse: insights from the Framingham Heart Study

Zhaozhuo Niu et al. J Thorac Dis. 2016 Aug.

Abstract

The Framingham Heart Study group has described the non-diagnostic variants may evolve into mitral valve prolapse over time. These non-diagnostic variants include minimal systolic displacement, and abnormal anterior coaptation which is measured on surface echocardiography. Computed tomography and cardiac magnetic resonance imaging are evolving and can assess the degree of mitral regurgitation (MR); imaging techniques aside, genetic and proteomic detection of mitral prolapse is also evolving. However, the genetic basis for mitral prolapse is complex and likely involves multiple genetic loci. The same is also true for work determining possible biomarkers associated with mitral prolapse. The present study may be useful in counseling patients with a family history of mitral prolapse. Registry data is therefore of paramount importance in providing unbiased insight into this common disease.

Keywords: Epidemiology; echocardiography; valvular heart disease.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Comment on

References

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