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. 2016 Oct 21;60(11):6969-6972.
doi: 10.1128/AAC.01456-16. Print 2016 Nov.

mgrB Mutations Mediating Polymyxin B Resistance in Klebsiella pneumoniae Isolates from Rectal Surveillance Swabs in Brazil

Caio Augusto Martins Aires  1 , Polyana Silva Pereira  1 , Marise Dutra Asensi  2 , Ana Paula D'Alincourt Carvalho-Assef  2
Affiliations

mgrB Mutations Mediating Polymyxin B Resistance in Klebsiella pneumoniae Isolates from Rectal Surveillance Swabs in Brazil

Caio Augusto Martins Aires et al. Antimicrob Agents Chemother. .

Abstract

We aimed to investigate polymyxin B (PMB) resistance and its molecular mechanisms in 126 Klebsiella pneumoniae isolates from rectal swabs in Brazil. Ten isolates exhibited PMB resistance with interruption of mgrB gene by insertion sequences or missense mutations. Most of the PMB-resistant isolates harbored blaKPC-2 (n = 8) and belonged to clonal complex 258 (CC258) (n = 7). These results highlight the importance of monitoring the spread of polymyxin-resistant bacteria in hospitals, since few options remain to treat multidrug-resistant isolates.

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Figures

FIG 1
FIG 1
Epidemiological and molecular typing of polymyxin B-resistant K. pneumoniae isolates analyzed in this work. DF, Distrito Federal; ES, Espírito Santo; PE, Pernambuco; RJ, Rio de Janeiro; RS, Rio Grande do Sul; ST, sequence type. The PFGE pulsotypes and subtypes (indicated by a superscript “a”) were defined as strains with at least 80% and 95% similarities, respectively.
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