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. 2016 Jun 27;5(8):e1200771.
doi: 10.1080/2162402X.2016.1200771. eCollection 2016 Aug.

Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer

Amir A Al-Khami  1 , Paulo C Rodriguez  2 , Augusto C Ochoa  3
Affiliations

Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer

Amir A Al-Khami et al. Oncoimmunology. .

Abstract

MDSC undergo metabolic reprogramming in the tumor resulting in an increased fatty acid β oxidation that supports their immunosuppressive functions. Fatty acid oxidation inhibitors, used to treat coronary disease, significantly delayed tumor growth and had a significantly increased antitumor effect when combined with adoptive cell therapy or low dose chemotherapy.

Keywords: Cancer; Immunometabolism; MDSC.

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Figures

Figure 1.
Figure 1.
Tumor-associated MDSC increase fatty acid uptake and activate FAO. Tumor-infiltrating MDSC show a heightened expression of lipid uptake receptors, such as CD36 and Msr1, thereby increasing fatty acid uptake. MDSC display an increased mitochondrial biogenesis and fatty acid oxidation. These events coincide with elevated immunosuppressive pathways, which block antitumor T cell responses.
See this image and copyright information in PMC

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