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. 1989 Feb;6(2):177-81.
doi: 10.1023/a:1015944912736.

The determination of microscopic ionization constants of a substituted piperazine using estimates from model compounds

N K Pandit  1 , J M Sisco
Affiliations

The determination of microscopic ionization constants of a substituted piperazine using estimates from model compounds

N K Pandit et al. Pharm Res. 1989 Feb.

Abstract

The microscopic ionization constants of 1-[3-(4-chlorophenyl) propyl] piperazine (I) were determined using piperazine (P) and 1,4-bis[3-(4-chlorophenyl)propyl] piperazine (II) as models for one of the ionizations. The macroscopic ionization constants for all three compounds were measured potentiometrically, and the micro constants of P and II, which are symmetrical molecules, were calculated from their macro constants. Only one micro constant of either P or II was suitable as a model for elucidating the micro constants of I.

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