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Review
. 2016 Oct;9(10):933-8.
doi: 10.1080/17474086.2016.1234933. Epub 2016 Sep 22.

Pathophysiology of the disturbed angiogenesis in hemophilia

E Carlos Rodriguez-Merchan  1
Affiliations
Review

Pathophysiology of the disturbed angiogenesis in hemophilia

E Carlos Rodriguez-Merchan. Expert Rev Hematol. 2016 Oct.

Abstract

Introduction: It has been reported an increase of angiogenesis and vascular remodeling in hemophilic arthropathy. Therefore, antiangiogenic drugs could be useful in the management of hemophilic arthropathy. The aim of this review paper is to revise the role of angiogenesis in hemophilic arthropathy.

Areas covered: This article is a narrative review of the pathophysiology of the disturbed angiogenesis in hemophilia and the potential role of antiangiogenic drugs in nonhemophilia patients Expert commentary: Antiangiogenic drugs could be helpful in the future for the treatment of hemarthroses in hemophilic arthropathy. However, despite some recent reports emphasizing the role of angiogenesis in hemophilia, as these drugs have never been investigated for the treatment of hemophilic arthropathy in PWH, it is clear that they are not indicated.

Keywords: Hemophilia; angiogenesis; antiangiogenic drugs; hemarthrosis; hemophilic arthropathy.

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