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Review
. 2017 Feb;13(3):285-293.
doi: 10.2217/fon-2016-0217. Epub 2016 Sep 14.

The emerging role of obesity, diet and lipid metabolism in prostate cancer

Matteo Ferro  1 , Daniela Terracciano  2 , Carlo Buonerba  3 , Giuseppe Lucarelli  4 , Danilo Bottero  1 , Sisto Perdonà  5 , Riccardo Autorino  6 , Alessandro Serino  1 , Francesco Cantiello  7 , Rocco Damiano  7 , Iulia Andras  8 , Sabino De Placido  3 , Giuseppe Di Lorenzo  3 , Michele Battaglia  4 , Barbara A Jereczek-Fossa  9   10 , Vincenzo Mirone  11 , Ottavio De Cobelli  1   8   12
Affiliations
Review

The emerging role of obesity, diet and lipid metabolism in prostate cancer

Matteo Ferro et al. Future Oncol. 2017 Feb.

Abstract

Obesity is associated with an increased risk of a number of serious medical conditions, including cancer. As far as prostate cancer is concerned, obesity is associated with an increased risk of high-grade tumors, which is possibly related to lower androgen levels. Diet may also affect prostate cancer risk since countries with a higher dietary fat intake also present higher prostate cancer mortality rates. Interestingly, prostate cancer is associated with a number of metabolic alterations that may provide valuable diagnostic and therapeutic targets. This review explores the available clinical as well as biological evidence supporting the relationship between obesity, diet, alteration in metabolic pathways and prostate cancer.

Keywords: diet; obesity; urologic/prostate.

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Conflict of interest statement

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. Adipocyte secreted factors with a role in prostate cancer development.
FFA: Free fatty acid.
See this image and copyright information in PMC

References

    1. Smith KB, Smith MS. Obesity statistics. Primary Care. 2016;43(1):121–135. - PubMed
    1. Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289(1):76–79. - PubMed
    1. De Sousa AG, Cercato C, Mancini MC, Halpern A. Obesity and obstructive sleep apnea–hypopnea syndrome. Obes Rev. 2008;9(4):340–354. - PubMed
    1. Wolin KY, Carson K, Colditz GA. Obesity and cancer. Oncologist. 2010;15(6):556–565. - PMC - PubMed
    1. Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–578. - PubMed

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