Selection and estimation for mixed graphical models
- PMID: 27625437
- PMCID: PMC5018402
- DOI: 10.1093/biomet/asu051
Selection and estimation for mixed graphical models
Abstract
We consider the problem of estimating the parameters in a pairwise graphical model in which the distribution of each node, conditioned on the others, may have a different exponential family form. We identify restrictions on the parameter space required for the existence of a well-defined joint density, and establish the consistency of the neighbourhood selection approach for graph reconstruction in high dimensions when the true underlying graph is sparse. Motivated by our theoretical results, we investigate the selection of edges between nodes whose conditional distributions take different parametric forms, and show that efficiency can be gained if edge estimates obtained from the regressions of particular nodes are used to reconstruct the graph. These results are illustrated with examples of Gaussian, Bernoulli, Poisson and exponential distributions. Our theoretical findings are corroborated by evidence from simulation studies.
Keywords: Compatibility; Conditional likelihood; Exponential family; High dimensionality; Model selection consistency; Neighbourhood selection; Pairwise Markov random field.
Figures







References
-
- Allen GI, Liu Z. Proc. IEEE Int. Conf. Bioinfo. Biomed. 2012. New York: Curran Associates; 2012. A log-linear graphical model for inferring genetic networks from high-throughput sequencing data; pp. 1–6.
-
- Besag JE. Spatial interaction and the statistical analysis of lattice systems (with Discussion) J. R. Statist. Soc. B. 1974;36:192–236.
-
- Bunea F. Honest variable selection in linear and logistic regression models via ℓ1 and + ℓ2 penalization. Electron. J. Statist. 2008;2:1153–1194.
-
- Fellinghauer B, Bühlmann P, Ryffel M, von Rhein M, Reinhardt JD. Stable graphical model estimation with random forests for discrete, continuous, and mixed variables. Comp. Statist. Data Anal. 2013;64:132–142.
-
- Finegold M, Drton M. Robust graphical modeling of gene networks using classical and alternative t-distributions. Ann. Appl. Statist. 2011;5:1057–1080.
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources