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Comment
. 2016 Sep 13;24(3):371-373.
doi: 10.1016/j.cmet.2016.08.022.

Specialized Hub Beta Cells Trade Maximal Insulin Production for Perfect Timing

Jelena Kolic  1 , James D Johnson  2
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Free article
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Specialized Hub Beta Cells Trade Maximal Insulin Production for Perfect Timing

Jelena Kolic et al. Cell Metab. .
Free article

Abstract

The pulsatility of insulin release is disturbed early in type 2 diabetes, but it is not clear whether specialized pacemaker cells drive islet oscillations. In this issue of Cell Metabolism, Johnston et al. (2016) show that specialized hubs, identified as 1%-10% of beta cells with more active mitochondria and less insulin, synchronize beta cell oscillations.

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  • Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose.
    Johnston NR, Mitchell RK, Haythorne E, Pessoa MP, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson M, Broichhagen J, Trauner D, Rutter GA, Hodson DJ. Johnston NR, et al. Cell Metab. 2016 Sep 13;24(3):389-401. doi: 10.1016/j.cmet.2016.06.020. Epub 2016 Jul 21. Cell Metab. 2016. PMID: 27452146 Free PMC article.

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