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Comment
. 2016;44(4):286-288.
doi: 10.1159/000449513. Epub 2016 Sep 15.

Should We Always Defer Treatment of Kidney Disease When There Is Extensive Interstitial Fibrosis on Biopsy?

Musab S Hommos  1 , Andrew D Rule
Affiliations
Comment

Should We Always Defer Treatment of Kidney Disease When There Is Extensive Interstitial Fibrosis on Biopsy?

Musab S Hommos et al. Am J Nephrol. 2016.

Abstract

Severity of interstitial fibrosis and tubular atrophy (IFTA) seen on kidney biopsy has been used by nephrologist as prognostic marker of kidney disease. While IFTA is a very strong predictor of kidney failure, some patients with severe fibrosis will still not progress to kidney failure within 5 years. Treatment of underlying kidney disease in select patients with severe IFTA should be considered when risks of treatment are reasonable despite the low potential for benefit.

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Conflict of interest statement

None

Comment on

References

    1. Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol. 2006;17(1):17–25. - PubMed
    1. Lv J, et al. Evaluation of the Oxford Classification of IgA nephropathy: a systematic review and meta-analysis. Am J Kidney Dis. 2013;62(5):891–899. - PubMed
    1. Solez K, et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant. 2008;8(4):753–760. - PubMed
    1. Menn-Josephy H, et al. Renal interstitial fibrosis: A useful yet imperfect prognostic indicator in chronic kidney disease. American Journal of Nephrology. 2016 - PMC - PubMed
    1. Denic A, et al. Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults. Am J Kidney Dis. 2016;68(1):58–67. - PMC - PubMed