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Review
. 2016 Oct 1;74(5):561-567.
doi: 10.1684/abc.2016.1177.

Cytogenetics in the management of chronic lymphocytic leukemia: an update by the Groupe francophone de cytogénétique hématologique (GFCH)

Florence Nguyen-Khac  1 , Claire Borie  2 , Evelyne Callet-Bauchu  3 , Virginie Eclache  4 , Stéphanie Struski  5
Affiliations
Free article
Review

Cytogenetics in the management of chronic lymphocytic leukemia: an update by the Groupe francophone de cytogénétique hématologique (GFCH)

Florence Nguyen-Khac et al. Ann Biol Clin (Paris). .
Free article

Abstract

Acquired recurrent cytogenetic abnormalities are frequent in chronic lymphocytic leukaemia (CLL). They can be associated with good or poor prognostic factors, and also with gene mutations. Chromosomal abnormalities could be clonal or sub-clonal. Assessing the TP53 status (deletion/mutation) is currently mandatory before treating patients. The search for 11q deletion (ATM gene) is also recommended. Finally, the prognostic value of other chromosomal abnormalities including complex karyotype is still debated.

Keywords: 17p deletion; CLL; TP53; cytogenetic abnormalities.

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