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. 2016 Sep 15:20:288.
doi: 10.1186/s13054-016-1470-7.

Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury

Imo P Aisiku  1 , Jose-Miguel Yamal  2 , Pratik Doshi  3 , Julia S Benoit  4 , Shankar Gopinath  5 , Jerry C Goodman  6 , Claudia S Robertson  5
Affiliations

Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury

Imo P Aisiku et al. Crit Care. .

Abstract

Background: Patients with severe traumatic brain injury (TBI) are at risk of the development of acute respiratory distress syndrome (ARDS). TBI and ARDS pathophysiologic mechanisms are known to independently involve significant inflammatory responses. The literature on the association between plasma inflammatory cytokines and ARDS in patients with TBI is sparse.

Methods: The study was a secondary analysis of the safety of a randomized trial of erythropoietin and transfusion threshold in patients with severe TBI. Inflammatory markers within the first 24 hours after injury were compared in patients who developed ARDS and patients without ARDS, using Cox proportional hazards models.

Results: There were 200 patients enrolled in the study. The majority of plasma and cerebrospinal fluid (CSF) cytokine levels were obtained within 6 hours. Plasma proinflammatory markers IL-6 and IL-8 and anti-inflammatory marker IL-10 were associated with the development of ARDS (adjusted hazard ratio (HR) = 1.55, confidence interval (CI) = 1.14, 2.11, P = 0.005 for IL-6; adjusted HR = 1.32, CI = 1.10, 1.59, P = 0.003 for IL-8).

Conclusion: Plasma markers of IL-6, IL-8, and IL-10 are associated with ARDS in patients with severe TBI.

Trial registration: NCT00313716 registered 4/2006.

Keywords: ALI; ARDS; CSF; Cytokines; Plasma; TBI.

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Figures

Fig. 1
Fig. 1
a Distribution of time of plasma cytokine measurement after injury. b Distribution of time of cerebrospinal fluid cytokine measurement after injury
See this image and copyright information in PMC

References

    1. Kadhim HJ, Duchateau J, Sebire G. Cytokines and brain injury: invited review. J Intensive Care Med. 2008;23(4):236–49. doi: 10.1177/0885066608318458. - DOI - PubMed
    1. Soriano SG, Piva S. Central nervous system inflammation. Eur J Anaesthesiol Suppl. 2008;42:154–9. doi: 10.1017/S0265021507003390. - DOI - PubMed
    1. Engelhardt B. Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines. J Neurol Sci. 2008;274(1-2):23–6. doi: 10.1016/j.jns.2008.05.019. - DOI - PubMed
    1. Schneider Soares FM, Menezes de Souza N, Liborio Schwarzbold M, et al. Interleukin-10 is an independent biomarker of severe traumatic brain injury prognosis. Neuroimmunomodulation. 2012;19(6):377–85. doi: 10.1159/000342141. - DOI - PubMed
    1. Lu J, Goh SJ, Tng PY, Deng YY, Ling EA, Moochhala S. Systemic inflammatory response following acute traumatic brain injury. Front Biosci. 2009;14:3795–813. doi: 10.2741/3489. - DOI - PubMed

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