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. 2016 Jul;11(7):1069-70.
doi: 10.4103/1673-5374.187030.

How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases?

Affiliations

How does zebrafish support new strategies for neuroprotection and neuroregeneration in hypoxia-related diseases?

Emerson S Silva et al. Neural Regen Res. 2016 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Representation of hypoxia systems used in zebrafish. In the left it is showed a closed system, suitable for the study of new therapeutic strategies for the treatment of cerebral dysfunctions involving low O2 levels. In the right it is showed an open system, used mainly for hypoxia tolerance tests. In this system the O2 from air is available to water.
Figure 2
Figure 2
Excitatory neuron located in the optic tectum of zebrafish containing round clear vesicles indicated by arrows. Scale bar: 200 μm. The methodological procedures performed for this sample were based on Hermel et al. (2006).

References

    1. Barrionuevo WR, Burggren WW. O2 consumption and heart rate in developing zebrafish (Danio rerio): influence of temperature and ambient O2. Am J Physiol. 1999;276:R505–513. - PubMed
    1. Braga MM, Rico EP, Córdova SD, Pinto CB, Blaser RE, Dias RD, Rosemberg DB, Oliveira DL, Souza DO. Evaluation of spontaneous recovery of behavioral and brain injury profiles in zebrafish after hypoxia. Behav Brain Res. 2013a;253:145–151. - PubMed
    1. Braga MM, Rosemberg DB, de Oliveira DL, Loss CM, Córdova SD, Rico EP, Silva ES, Dias RD, Souza DO, Calcagnotto ME. Topographical analysis of reactive zinc in the central nervous system of adult zebrafish (Danio rerio) Zebrafish. 2013b;10:376–388. - PMC - PubMed
    1. Braga MM, Silva ES, Rico EP, Pettenuzzo LF, Oliveira DL, Dias RD, Rocha JBT, Calcagnotto ME, Tanguay RL, Souza DO, Rosemberg DB. Modulation of the chelatable Zn pool in the brain by diethyldithiocarbamate is associated with behavioral impairment in adult zebrafish. Toxicol Res. 2015;4:317–325.
    1. Braga MM, Silva ES, Moraes TB, Schirmbeck GH, Rico EP, Pinto CB, Rosemberg DB, Dutra-Filho CS, Dias RD, Oliveira DL, Rocha JBT, Souza DO. Brain zinc chelation by diethyldithiocarbamate increased the behavioral and mitochondrial damages in zebrafish subjected to hypoxia. Sci Rep. 2016;6:20279. - PMC - PubMed