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. 2016 Jul;10(7):FC01-4.
doi: 10.7860/JCDR/2016/16911.8121. Epub 2016 Jul 1.

Valproic Acid versus Lamotrigine as First-line Monotherapy in Newly Diagnosed Idiopathic Generalized Tonic -Clonic Seizures in Adults - A Randomized Controlled Trial

Vishal Prakash Giri  1 , Om Prakash Giri  2 , Farhan Ahmad Khan  3 , Narendra Kumar  4 , Ajay Kumar  5 , Ataul Haque  6
Affiliations

Valproic Acid versus Lamotrigine as First-line Monotherapy in Newly Diagnosed Idiopathic Generalized Tonic -Clonic Seizures in Adults - A Randomized Controlled Trial

Vishal Prakash Giri et al. J Clin Diagn Res. 2016 Jul.

Abstract

Introduction: Idiopathic Generalized Tonic-Clonic Seizures (GTCS) are frequently encountered in adults. Their successful control is necessary to improve the quality of life of these patients. Valproic acid is a simple branched-chain carboxylic acid and lamotrigine is a phenyltriazine derivative. Opinions differ in regards to their effectiveness in idiopathic GTCS.

Aim: To compare the effectiveness of valproic acid and lamotrigine in newly diagnosed adults with idiopathic generalized tonic-clonic seizures.

Materials and methods: The present prospective randomized study was conducted on 60 patients suffering from idiopathic GTCS. Thirty patients received valproic acid and rest 30 patients received lamotrigine. All patients were followed regularly monthly for one year for treatment response and adverse effects.

Results: After 12 months follow-up, 76.67% patients taking valproic acid and 56.67% patients taking lamotrigine were seizure-free. Common adverse effects recorded were nausea, dyspepsia, headache and skin rash.

Conclusion: Valproic acid is more effective than lamotrigine as first-line drug in the treatment of adults with newly diagnosed idiopathic generalized tonic-clonic seizures.

Keywords: Antiepileptic drugs; Clinical trial; Effectiveness; Epilepsy; Monotherapy.

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Figures

[Table/Fig-7]:
[Table/Fig-7]:
Flow chart of the study participants.
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