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Review
. 2017 Feb;20(1):70-75.
doi: 10.1007/s11102-016-0744-z.

Complications of acromegaly: thyroid and colon

Amit Tirosh  1   2 , Ilan Shimon  3   4
Affiliations
Review

Complications of acromegaly: thyroid and colon

Amit Tirosh et al. Pituitary. 2017 Feb.

Abstract

Introduction: In acromegaly the long-term exposure to high growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels may result in specific complications in different human organs, including the thyroid gland and the colon.

Materials and methods: We will review here the evidence available regarding the characteristic thyroid and colon complications in acromegaly.

Results: This review summarizes the published data observing noncancerous structural abnormalities (thyroid nodules, colonic polyps) and thyroid and colon cancer in patients diagnosed with acromegaly.

Conclusion: Thyroid micro-carcinomas are probably over-diagnosed among acromegalic patients. In regard to colon cancer, there is no sufficient data to suggest that colon cancer risk is higher in acromegaly compared to the general population.

Keywords: Acromegaly; Colon; Thyroid.

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