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Comment
. 2016 Nov;26(11):1178-1179.
doi: 10.1038/cr.2016.107. Epub 2016 Sep 16.

A new edge to immune surveillance by the neural system

Jochem H Bernink  1 , Hergen Spits  1 , Wouter J de Jonge  2
Affiliations
Comment

A new edge to immune surveillance by the neural system

Jochem H Bernink et al. Cell Res. 2016 Nov.

Abstract

A recent paper published in Nature demonstrates a multifaceted relation between enteric glial cells (EGC), intestinal epithelia, and ILC3, via the EGC release of neurotrophic factors, a structurally related group of ligands within the TGF-β superfamily of signaling molecules and IL-22 produced by ILC3.

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Figure 1
Figure 1
Glial cells that surround ILC3 aggregates such as in cryptopatches and ILF are directly activated by (1) TLR ligands and (2) IL-1β, which results in the secretion of (3) neurotrophic factors that bind to the RTK on ILC3. Ret-activated ILC3 in turn secretes IL-22 (4) enhancing epithelial cell reactivity.
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