Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Oct 15;26(20):4947-4949.
doi: 10.1016/j.bmcl.2016.09.010. Epub 2016 Sep 6.

Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging

Xiaolei Wang  1 , Miho Emoto  2 , Yusuke Miyake  3 , Kaori Itto  1 , Shu Xu  1 , Hirotada Fujii  2 , Hiroshi Hirata  3 , Hirokazu Arimoto  4
Affiliations

Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging

Xiaolei Wang et al. Bioorg Med Chem Lett. .

Abstract

A novel blood-brain barrier (BBB)-permeable compound 10 was discovered, wherein the nitroxide moiety was linked to a nicotine acetylcholine receptor ligand. It was applied as a probe for electron paramagnetic resonance (EPR) imaging of the mouse brain. The results demonstrated that the newly synthesized compound 10 exhibited BBB permeability. These findings provide an essential discovery for in vivo EPR imaging.

Keywords: Blood–brain barrier permeable; EPR brain imaging; Nitroxide; Spin probe.

PubMed Disclaimer

Publication types

LinkOut - more resources