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Review
. 2016 Oct 18;7(42):69087-69096.
doi: 10.18632/oncotarget.12011.

Prognostic and clinicopathological value of Gli-1 expression in gastric cancer: A meta-analysis

Li Lu  1 , Menglin Wu  2 , Feixiang Zhao  2 , Weihua Fu  1 , Weidong Li  1 , Xue Li  2 , Tong Liu  1
Affiliations
Review

Prognostic and clinicopathological value of Gli-1 expression in gastric cancer: A meta-analysis

Li Lu et al. Oncotarget. .

Abstract

Glioma associated oncogene-1 (Gli-1) is considered as a strong positive activator of downstream target genes of hedgehog signal pathway in mammalians. However, its diagnostic and prognostic value in gastric cancer remains unclear and controversial. Therefore, a quantitative meta-analysis was conducted to determine the clinical value of Gli-1 in gastric cancer patients. Twelve eligible articles with 886 gastric cancer patients were included in this meta-analysis. The relationship between Gli-1 expression in gastric cancer patients and clinicopathological features and 5-year overall survival (OS) was evaluated using pooled odds ratios (ORs) and hazard ratio (HR) with 95% confidence intervals (CIs). The meta-analysis showed that the upregulated Gli-1 was associated with sample type (gastric cancer tissues) (OR 10.31, 95%CI 7.14-14.88; P = 0.000), differentiation type (OR 3.76, 95%CI 2.55-5.53; P = 0.000), depth of invasion (OR 8.17, 95%CI 3.60-18.55; P = 0.000), lymph node metastasis (OR 3.97, 95%CI 2.73-5.78; P = 0.000) and high TNM stage (OR 3.65, 95%CI 1.89-7.04; P = 0.000). Three studies including 316 patients were assessed for the correlation between Gli-1 and 5-year OS, which indicated that positive Gli-1 expression was associated with poor prognosis in gastric cancer patients (HR 2.14, 95%CI 1.35-3.40; P = 0.001). Little publication bias was identified by funnel plots and Egger's tests. The sensitivity analysis indicated that no study substantially influenced pooled OR/HR. Taken together, Gli-1 is a credible indicator for highly aggressive tumor with poor prognosis in gastric cancer patients.

Keywords: Gli-1; gastric cancer; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Flow chat of study selection
Figure 2
Figure 2
A. Forest plot of studies evaluating the relationship between Gli-1 expression and gender. B. Forest plot of studies evaluating the relationship between Gli-1 expression and sample type. C. Forest plot of studies evaluating the relationship between Gli-1 expression and tumor location. D. Forest plot of studies evaluating the relationship between Gli-1 expression and tumor size.
Figure 3
Figure 3
A. Forest plot of studies evaluating the relationship between Gli-1 expression and differentiation type. B. Forest plot of studies evaluating the relationship between Gli-1 expression and depth of invasion. C. Forest plot of studies evaluating the relationship between Gli-1 expression and lymph node metastasis. D. Forest plot of studies evaluating the relationship between Gli-1 expression and TNM.
Figure 4
Figure 4. Forest plot of studies evaluating the relationship between Gli-1 expression and 5-year overall survival
Figure 5
Figure 5. Funnel plot for publication bias test of Gli-1 related studies
A., Gender; B., Sample type; C., Tumor location; D., Tumor size; E., Differentiation type; F., Depth of invasion; G., Lymph node metastasis; H., TNM; I., 5-year overall survival.
See this image and copyright information in PMC

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