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Review
. 2016 Oct:106:91-8.
doi: 10.1016/j.critrevonc.2016.08.002. Epub 2016 Aug 10.

The role of IL-29 in immunity and cancer

Noah E Kelm  1 , Ziwen Zhu  2 , Vivi A Ding  1 , Huaping Xiao  3 , Mark R Wakefield  2 , Qian Bai  2 , Yujiang Fang  4
Affiliations
Review

The role of IL-29 in immunity and cancer

Noah E Kelm et al. Crit Rev Oncol Hematol. 2016 Oct.

Abstract

Interleukin-29 (IL-29) is a new member of the recently discovered interferon λ (IFNλ) family. It is produced predominantly by maturing dendritic cells and macrophages. It has been implicated in numerous immunological responses and has shown antiviral activity similar to the Type I interferons, although its target cell population is more limited than the Type I interferons. In recent years, the role of IL-29 in the pathogenesis of various cancers has also been extensively studied. In this review, we will discuss the recent advances of IL-29 in immunological processes and the pathogenesis of various cancer.

Keywords: Cancer; Cytokine; IL-29; Immune response.

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