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Review
. 2016 Oct;12(4):499-506.
doi: 10.1016/j.hfc.2016.06.007.

Genetics of Takotsubo Syndrome

Giuseppe Limongelli  1 , Daniele Masarone  2 , Valeria Maddaloni  3 , Marta Rubino  2 , Fiorella Fratta  2 , Annapaola Cirillo  2 , Spinelli Barrile Ludovica  2 , Roberta Pacileo  2 , Adelaide Fusco  2 , Guido Ronald Coppola  2 , Francesca Pisacane  2 , Eduardo Bossone  4 , Paolo Calabrò  2 , Raffaele Calabrò  2 , Maria Giovanna Russo  2 , Giuseppe Pacileo  2
Affiliations
Review

Genetics of Takotsubo Syndrome

Giuseppe Limongelli et al. Heart Fail Clin. 2016 Oct.

Abstract

Takotsubo syndrome (TTS) is an enigmatic disease with a multifactorial and still unresolved pathogenesis. A genetic predisposition has been suggested based on the few familial TTS cases. Conflicting results have been published regarding the role of functional polymorphisms in relevant candidate genes, such as α1-, β1-, and β2-adrenergic receptors; G protein-coupled receptor kinase 5; and estrogen receptors. Further research is required to help clarify the role of genetic susceptibility in TTS.

Keywords: Adrenoceptor polymorphisms; Catecholamine-induced myocardial toxicity; Takotsubo syndrome.

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