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Review
. 2016 Dec;129(12):1251-1258.
doi: 10.1016/j.amjmed.2016.08.032. Epub 2016 Sep 14.

Isolated Systolic Hypertension: An Update After SPRINT

Chirag Bavishi  1 , Sangita Goel  2 , Franz H Messerli  3
Affiliations
Review

Isolated Systolic Hypertension: An Update After SPRINT

Chirag Bavishi et al. Am J Med. 2016 Dec.

Erratum in

Abstract

Isolated systolic hypertension is the most common hemodynamic form of hypertension in the elderly. With a rapidly aging population, the prevalence of hypertension, particularly isolated systolic hypertension, is expected to increase substantially. This phenomenon of increasing systolic pressure in the elderly is believed to be secondary to pathophysiological changes of aging as well as modifiable risk factors. Isolated systolic hypertension is associated with substantial mortality and morbidity, particularly of cerebrovascular disease. It is a rapidly growing public health concern and its management continues to remain a challenge to practicing physicians. Recent studies like the Systolic Blood Pressure Intervention Trial (SPRINT) and Heart Outcomes Prevention Evaluation (HOPE)-3 have implications for antihypertensive therapy in general and for the management of isolated systolic hypertension in particular. In this article we will review: 1) epidemiology and pathophysiologic mechanisms, 2) impact of isolated systolic hypertension on cardiovascular outcomes, 3) optimal management strategies, and 4) systolic blood pressure goals in the light of SPRINT and HOPE 3 trials.

Keywords: Elderly; Hypertension; Systolic.

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Comment in

  • Blood Pressure Goals in Functionally Limited Elderly Patients.
    Bahat G, İlhan B, Tufan A, Karan MA. Bahat G, et al. Am J Med. 2017 Jul;130(7):e319-e320. doi: 10.1016/j.amjmed.2016.12.045. Am J Med. 2017. PMID: 28619373 No abstract available.
  • The Reply.
    Bavishi C, Goel S, Messerli FH. Bavishi C, et al. Am J Med. 2017 Jul;130(7):e321. doi: 10.1016/j.amjmed.2017.03.005. Am J Med. 2017. PMID: 28619374 No abstract available.
  • An Elderly Physician's Plea.
    Luger SW. Luger SW. Am J Med. 2018 Jan;131(1):e25. doi: 10.1016/j.amjmed.2017.06.036. Am J Med. 2018. PMID: 29224613 No abstract available.
  • The Reply.
    Bavishi C, Messerli FH. Bavishi C, et al. Am J Med. 2018 Jan;131(1):e27. doi: 10.1016/j.amjmed.2017.09.006. Am J Med. 2018. PMID: 29224614 No abstract available.

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