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. 1978 Jun 20;11(2):171-87.
doi: 10.1007/BF01733892.

Biotin. Its place in evolution

C M Visser, R M Kellogg

Biotin. Its place in evolution

C M Visser et al. J Mol Evol. .

Abstract

In the previous article we try to give an explanation for the success of models of enzymatic reactions in which coenzymes play a role. However, one vital cofactor that has thus far not yielded appreciably to this approach is biotin. We attempt to show that biotin presents a fundamentally new sort of problem to bioorganic chemistry; this problem requires consideration both of the origin of life and subsequent evolution in any attempt to understand the anomalies offered by this cofactor.

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