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. 2016 Nov;114(6):743-751.
doi: 10.1002/jso.24402. Epub 2016 Sep 19.

Prognostic value of occult tumor cells obtained by peritoneal lavage in patients with resectable pancreatic cancer and no ascites: A systematic review

Willemijn Steen  1 , Rachel Blom  1 , Olivier Busch  2 , Michael Gerhards  1 , Marc Besselink  2 , Frederike Dijk  3 , Sebastiaan Festen  4
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Prognostic value of occult tumor cells obtained by peritoneal lavage in patients with resectable pancreatic cancer and no ascites: A systematic review

Willemijn Steen et al. J Surg Oncol. 2016 Nov.

Abstract

The poor survival of patients with resectable pancreatic cancer might be related to the presence of occult peritoneal tumor cells (OPTC). This systematic review studies the prognostic value of cytology and carcinoembryonic antigen (CEA) by real-time polymerase chain reaction in peritoneal fluid. The results suggest that presence of OPTC is related to a worse survival in patients with resectable pancreatic cancer. Future studies should investigate its possible role in selecting patients for specific treatment strategies. J. Surg. Oncol. 2016;114:743-751. © 2016 Wiley Periodicals, Inc.

Keywords: CEA; RT-PCR; cytology; occult tumor cells; pancreatic cancer; peritoneal fluid.

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