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. 2015 Dec;31(12):1258-1260.
doi: 10.13865/j.cnki.cjbmb.2015.12.05.

Mechanism and Function of Angiogenin in Apoptosis Regulation

L I Shu-Ping  1 , H U Guo-Fu  1
Affiliations

Mechanism and Function of Angiogenin in Apoptosis Regulation

L I Shu-Ping et al. Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao. 2015 Dec.

Abstract

Angiogenin (ANG), a secreted ribonuclease, has been characterized recently as an anti-apoptosis factor involved in a variety of cellular anti-apoptosis process. ANG regulates intrinsic pathways-related major molecules such as anti-apoptotic protein Bcl-2, as well as extrinsic signaling pathways. Moreover, ANG regulates p53-regulated apoptosis, a process considered to be important in regulating both the extrinsic and the intrinsic pathways.

Keywords: Bcl-2; angiogenin; apoptosis; p 53.

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