doi: 10.1002/asia.201601164.
Epub 2016 Oct 12.
Rhodium/Silver-Cocatalyzed Transannulation of N-Sulfonyl-1,2,3-triazoles with Vinyl Azides: Divergent Synthesis of Pyrroles and 2 H-Pyrazines
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- PMID: 27643511
- DOI: 10.1002/asia.201601164
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Rhodium/Silver-Cocatalyzed Transannulation of N-Sulfonyl-1,2,3-triazoles with Vinyl Azides: Divergent Synthesis of Pyrroles and 2 H-Pyrazines
Chem Asian J.
.
Abstract
The first cyclization reaction between vinyl azides and N-sulfonyl-1,2,3-triazoles is reported. A Rh/Ag binary metal catalyst system proved to be necessary for the successful cyclization. By varying the structure of vinyl azides, such reaction allows the divergent synthesis of pyrroles and 2H-pyrazines. The cyclization reactions feature a broad substrate scope, good functional group tolerance, high reaction efficiency, and good to high product yields.
Keywords: pyrazines; pyrroles; rhodium; silver; sulfonyl-1,2,3-triazoles; vinyl azides.
© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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