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Review
. 2017 Jan;131(1):125-133.
doi: 10.1007/s11060-016-2278-7. Epub 2016 Sep 19.

Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis

Akshitkumar M Mistry  1 , Andrew T Hale  2 , Lola B Chambless  1 , Kyle D Weaver  1 , Reid C Thompson  1 , Rebecca A Ihrie  3   4
Affiliations
Review

Influence of glioblastoma contact with the lateral ventricle on survival: a meta-analysis

Akshitkumar M Mistry et al. J Neurooncol. 2017 Jan.

Abstract

The ventricular-subventricular zone (V-SVZ), which lies in the walls of the lateral ventricles (LV), is the largest neurogenic niche within the adult brain. Whether radiographic contact with the LV influences survival in glioblastoma (GBM) patients remains unclear. We assimilated and analyzed published data comparing survival in GBM patients with (LV+GBM) and without (LV-GBM) radiographic LV contact. PubMed, EMBASE, and Cochrane electronic databases were searched. Fifteen studies with survival data on LV+GBM and LV-GBM patients were identified. Their Kaplan-Meier survival curves were digitized and pooled for generation of median overall (OS) and progression free (PFS) survivals and log-rank hazard ratios (HRs). The log-rank and reported multivariate HRs after accounting for the common predictors of GBM survival were analyzed separately by meta-analyses. The calculated median survivals (months) from pooled data were 12.95 and 16.58 (OS), and 4.54 and 6.25 (PFS) for LV+GBMs and LV-GBMs, respectively, with an overall log-rank HRs of 1.335 [1.204-1.513] (OS) and 1.387 [1.225-1.602] (PFS). Meta-analysis of log-rank HRs resulted in summary HRs of 1.58 [1.35-1.85] (OS, 10 studies) and 1.41 [1.22-1.64] (PFS, 5 studies). Meta-analysis of multivariate HRs resulted in summary HRs of 1.35 [1.14-1.58] (OS, 6 studies) and 1.64 [0.88-3.05] (PFS, 3 studies). Patients with GBM contacting the LV have lower survival. This effect may be independent of the common predictors of GBM survival, suggesting a clinical influence of V-SVZ contact on GBM biology.

Keywords: Glioblastoma; Glioma; Lateral ventricle; SVZ; Subventricular zone; V-SVZ; Ventricular-subventricular zone.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Cumulative Kaplan–Meier overall (a) and progression free (b) survival curves
Fig. 2
Fig. 2
Meta-analyses of log-rank HRs comparing overall (a) and progression free (c) survival in LV+GBM and LV−GBM patients. b, d Funnel plots demonstrating publication bias for a and c meta-analyses, respectively. Lines represent 95 % confidence interval obtained after trim and fill analysis. Each open circle represents a study included in the meta-analysis. Closed, dark circles represent non-existent studies compensating for publication bias with the trim and fill method. The resulting summary HR and confidence interval is represented by a closed, dark diamond
Fig. 3
Fig. 3
Meta-analyses of published multivariate HRs comparing overall (a) and progression free (c) survival in LV+GBM and LV−GBM patients. b, d Funnel plots demonstrating publication bias for a and c meta-analyses, respectively. Lines represent 95 % confidence interval obtained after trim and fill analysis. Each open circle represents a study included in the meta-analysis. Closed, dark circles represent non-existent studies compensating for publication bias with the trim and fill method and resulting summary HR and confidence interval is represented as a closed, dark diamond. These analyses were not performed in d
See this image and copyright information in PMC

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