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Meta-Analysis
. 2016 Sep 20:6:33658.
doi: 10.1038/srep33658.

Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis

Ping Zeng  1 , Min-Bin Chen  1 , Li-Na Zhou  1 , Min Tang  1 , Chao-Ying Liu  2 , Pei-Hua Lu  2
Affiliations
Meta-Analysis

Impact of TROP2 expression on prognosis in solid tumors: A Systematic Review and Meta-analysis

Ping Zeng et al. Sci Rep. .

Abstract

Over-expression of TROP2 (the trophoblast cell surface antigen 2) was reported to predict poor prognosis in various solid tumors in number of studies. However, the results remained not comprehensive. Therefore, we here carried out this meta-analysis of relevant studies published on this topic to quantitatively evaluate the clinicopathological significance of TROP2 in solid tumors. Relevant articles were identified through searching the PubMed, Web of Science and Embase database. The primary outcomes were overall survival (OS) and disease-free survival (DFS). In this meta-analysis, 16 studies involving 2,569 participants were included, and we drew the conclusion that TROP2 overexpression was significantly associated with poor OS (pooled HR = 1.896, 95% CI = 1.599-2.247, P < 0.001) and short DFS (pooled HR = 2.336, 95% CI = 1.596-3.419, P < 0.001). Furthermore, the subgroup analysis revealed that the associations between TROP2 overexpression and the outcome endpoints (OS or DFS) were significant in in patients with female genital system neoplasms, as well in gastrointestine neoplasms. In addition, subgroup analysis found no difference HR across populations of different descent.Taken together, TROP2 overexpression was associated with poor survival in human solid tumors. TROP2 may be a valuable prognosis predictive biomarker and a potential therapeutic target in human solid tumors.

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Figures

Figure 1
Figure 1. The flow chart of the selection process in our meta-analysis.
Figure 2
Figure 2. The correlation between TROP2 expression and overall survival (OS) in solid tumors.
Figure 3
Figure 3. The correlation between TROP2 expression and disease-free survival (DFS) in solid tumors.
Figure 4
Figure 4. Begg’s funnel plots for the studies involved in the meta-analysis.
(A) Overall survival. (B) disease-free survival(DFS). Abbreviations: loghr, logarithm of hazard ratios; s.e., standard error.
Figure 5
Figure 5. Sensitivity analysis of the meta-analysis.
(A) Overall survival. (B) disease-free survival (DFS).
See this image and copyright information in PMC

References

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