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. 2017 Feb;31(3):253-260.
doi: 10.1080/14786419.2016.1230114. Epub 2016 Sep 19.

A new phenone from the roots of Paeonia suffruticosa Andrews

Liqin Ding  1 , Qingfei Zuo  1 , Dandan Li  1 , Xinchi Feng  2 , Xiumei Gao  1 , Feng Zhao  3 , Feng Qiu  1   2
Affiliations

A new phenone from the roots of Paeonia suffruticosa Andrews

Liqin Ding et al. Nat Prod Res. 2017 Feb.

Abstract

Thirteen phenones were obtained from the 70% ethanol extract of Paeonia suffruticosa Andrews. Their structures were determined on the basis of chemical methods and spectral data. Among them, compound 1 was identified as a new compound, and compounds 5 and 13 were obtained from genus Paeonia for the first time. The inhibitory effects of isolated compounds (1-12) on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated, and NO production was suppressed significantly by compound 7.

Keywords: Paeonia suffruticosa Andrews; nitric oxide; phenones.

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