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Case Reports
. 2016 Dec;132(6):931-933.
doi: 10.1007/s00401-016-1618-1. Epub 2016 Sep 19.

[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration

Keith A Josephs  1 , Jennifer L Whitwell  2 , Pawel Tacik  3 , Joseph R Duffy  4 , Matthew L Senjem  5 , Nirubol Tosakulwong  6 , Clifford R Jack  2 , Val Lowe  2 , Dennis W Dickson  3 , Melissa E Murray  3
Affiliations
Case Reports

[18F]AV-1451 tau-PET uptake does correlate with quantitatively measured 4R-tau burden in autopsy-confirmed corticobasal degeneration

Keith A Josephs et al. Acta Neuropathol. 2016 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
Autopsy findings (a), autoradiography (b) and scatter-plots showing the relationship between tau-PET SUVR and tau burden at autopsy, as well as other measures of neurodegeneration (c). Panel a shows the tau burden assessment in our patient with CBD. Top image shows the tau immunostained tissue (CP13, mouse IgG1, 1:1000, Peter Davies, Albert Einstein College of Medicine, Bronx, NY), with the bottom image showing the custom-designed color deconvolution algorithm to highlight tau deposition (shown in red). Characteristic astrocytic plaques (arrow), ballooned neurons (dashed arrow), and thread-like processes (arrowhead) were observed and quantified. (Scale bar = 50 μm). Images shown are from inferior frontal cortex. Panel b shows tau immunohistochemistry and correlative autoradiography. Top row shows tau immunohistochemistry with PHF-1(1:1000 mouse monoclonal anti-phospho-serine 396/404 tau, gift from Peter Davies), 4R tau and 3R tau (RD4 and RD3, mouse IgG, Millipore, Temecula, CA) going from left to right (note 3R tau staining was negative) and bottom row shows [18F]AV-1451 autoradiography and [18F]AV-1451 blocked autoradiography in the nucleus accumbens. There was minimal, displaceable [18F]AV-1451 autoradiography binding corresponding to regions where 4R burden was most dense on immunohistochemistry. Panel c shows scatter-plots of the relationship between tau-PET SUVR and tau burden at autopsy, FDG-PET SUVR, MRI z-scores, and MRI rates of atrophy. The tau-PET data used in the correlation with tau burden at autopsy was calculated over grey and white matter within the ROI, whereas the tau-PET data used in the imaging plots was calculated over grey matter only to match the FDG and MRI data.
Fig. 2
Fig. 2
Tau-PET, PiB-PET, FDG-PET and MRI from our CBD patient. The tau-PET findings are shown on representative axial slices through the brain and in a box-plot showing regional SUVR values for the left and right hemisphere. Regional values were generated using the automated anatomical labeling atlas, with boxes representing median, 25th and 75th percentile values across all the voxels in each region. The red dots represent the median tau-PET SUVRs from a group of controls matched by age and gender to our patient. Tau-PET revealed increased signal in the putamen, pallidum, thalamus, precentral cortex, rolandic operculum, supplemental motor area, and left Broca’s area (frontal inferior opercular and frontal inferior triangularis). The PiB-PET, FDG-PET and MRI scans are also shown on representative axial slices. The three PET scans are shown on the same color scale while MRI scan highlights regions with z-scores between -2 and -4 standard deviations from controls. No increased signal was observed on PiB-PET. The FDG-PET revealed hypometabolism in the caudate nucleus, insula and throughout the posterior frontal lobes, including medial and lateral premotor and primary motor cortices, with greater abnormalities observed in the left hemisphere. The MRI showed more widespread abnormalities throughout the brain, although the most severe atrophy was observed in the frontal lobe. Inf = inferior, Mid = middle, Sup = superior, Ant = anterior, Post = posterior, Orb = orbital, Tri = triangularis.
See this image and copyright information in PMC

References

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