Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Jun;33(6):980-2.
doi: 10.1128/AAC.33.6.980.

Influence of etoposide and cyclophosphamide on the efficacy of cloxacillin and erythromycin in an experimental staphylococcal infection

W Calame  1 , R van der Waals, H Mattie, R van Furth
Affiliations

Influence of etoposide and cyclophosphamide on the efficacy of cloxacillin and erythromycin in an experimental staphylococcal infection

W Calame et al. Antimicrob Agents Chemother. 1989 Jun.

Abstract

The effect of monocytopenia and granulocytopenia on the outgrowth of Staphylococcus aureus as well as on antibiotic efficacy was studied in an experimental thigh infection in mice. Pretreatment with etoposide reduced monocyte numbers in blood to 14% and those of granulocytes to 54% at the time of infection. Monocytopenia did not affect the proliferation of bacteria in the infected thigh or the reduction of bacterial numbers after treatment with cloxacillin or erythromycin. Pretreatment with cyclophosphamide reduced monocyte numbers to 15% and granulocyte numbers to 3%. This resulted in a marked increase in the number of bacteria at the site of infection and a decrease in the efficacy of antibiotic treatment.

PubMed Disclaimer

References

    1. Blood. 1977 Jul;50(1):141-54 - PubMed
    1. J Infect Dis. 1978 Apr;137(4):391-402 - PubMed
    1. Infection. 1984 Jan-Feb;12(1):5-9 - PubMed
    1. Antimicrob Agents Chemother. 1988 Sep;32(9):1456-7 - PubMed
    1. J Infect Dis. 1986 Jan;153(1):90-7 - PubMed

Publication types