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Review
. 2016 Nov;18(11):56.
doi: 10.1007/s11894-016-0530-0.

Intestinal Transplant Inflammation: the Third Inflammatory Bowel Disease

Alexander Kroemer  1 , Christopher Cosentino  2 , Jason Kaiser  2 , Cal S Matsumoto  2 , Thomas M Fishbein  2
Affiliations
Review

Intestinal Transplant Inflammation: the Third Inflammatory Bowel Disease

Alexander Kroemer et al. Curr Gastroenterol Rep. 2016 Nov.

Abstract

Intestinal transplantation is the most immunologically complex of all abdominal organ transplants. Understanding the role both humoral and innate and adaptive cellular immunity play in intestinal transplantation is critical to improving outcomes and increasing indications for patients suffering from intestinal failure. Recent findings highlighting the impact of donor-specific antibodies on intestinal allografts, the role of NOD2 as a key regulator of intestinal immunity, the protective effects of innate lymphoid cells, and the role of Th17 in acute cellular rejection are reviewed here.

Keywords: Antimicrobial peptides; Donor-specific antibodies; Innate lymphoid cells; Intestinal transplantation; NOD2; Th17 cells.

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References

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