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Review
. 2016 Oct;24(5):291-293.
doi: 10.1007/s10787-016-0283-2. Epub 2016 Sep 19.

LPS and neuroinflammation: a matter of timing

Patricia C Lopes  1
Affiliations
Review

LPS and neuroinflammation: a matter of timing

Patricia C Lopes. Inflammopharmacology. 2016 Oct.

Abstract

Lipopolysaccharide (LPS) administration has been repeatedly shown to elicit central inflammation, regardless of the route of administration. In a recent study, Tiwari et al. (Inflammopharmacology 10.1007/s10787-016-0274-3 , 2016) dispute the potential of peripheral administration of LPS to induce neuroinflammation. Here, I summarise literature indicating that the neuroinflammatory effects of LPS are time dependent, and suggest that their findings can be explained by the time at which they chose to measure neuroinflammation.

Keywords: Lipopolysaccharide; Neuroinflammation; Time-dependent effects.

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References

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