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. 2016 Aug 11;13(9):696-700.
doi: 10.7150/ijms.16259. eCollection 2016.

Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy

Cheng-Hsueh Lee  1 , Jiunn-Bey Pao  2 , Te-Ling Lu  3 , Hong-Zin Lee  3 , Yung-Chin Lee  4 , Chia-Chu Liu  4 , Chao-Yuan Huang  5 , Victor C Lin  6 , Chia-Cheng Yu  7 , Hsin-Ling Yin  8 , Shu-Pin Huang  9 , Bo-Ying Bao  10
Affiliations

Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy

Cheng-Hsueh Lee et al. Int J Med Sci. .

Abstract

Backgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We hypothesized that genetic variants of PTGS2 can influence the outcome of prostate cancer patients.

Methods: We genotyped five haplotype-tagging single-nucleotide polymorphisms (SNPs) to detect common genetic variations across the PTGS2 region in 458 prostate cancer patients treated with radical prostatectomy.

Results: One SNP, rs4648302, was associated with disease recurrence. Five-year recurrence-free survival rate increased according to the number of variant alleles inherited (55.6%, 70.7%, and 100.0% for patients with different genotypes; P = 0.037), and the effect was maintained in multivariable analysis. Public dataset analyses also suggested that PTGS2 expression was correlated with prostate cancer prognosis.

Conclusion: Our results indicated that PTGS2 could be a potential prognostic marker to improve the prediction of disease recurrence in prostate cancer patients.

Keywords: PTGS2; biochemical recurrence; inflammation.; prostate cancer; radical prostatectomy; single-nucleotide polymorphism.

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Conflict of interest statement

The authors have declared that no conflict of interest exists.

Figures

Figure 1
Figure 1
Kaplan-Meier analysis of BCR-free survival based on PTGS2 rs4648302 genotypes. Numbers in parentheses indicate the number of patients.
Figure 2
Figure 2
Kaplan-Meier analysis of progression-free survival based on PTGS2 expression. Expression of PTGS2 mRNA is compared with progression-free survival in datasets from (A) Nakagawa et al., (B) Sboner et al., and (C) in combined analysis. Patients were divided into high and low groups according to the median mRNA expression values of PTGS2. Numbers in parentheses indicate the number of patients.
See this image and copyright information in PMC

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