Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul-Aug;32(4):880-5.
doi: 10.12669/pjms.324.9908.

Interleukin-6 polymorphisms and risk of coronary artery diseases in a Chinese population: A case-control study

Yao Hongmei  1 , Jia Yongping  2 , Lv Jiyuan  3
Affiliations

Interleukin-6 polymorphisms and risk of coronary artery diseases in a Chinese population: A case-control study

Yao Hongmei et al. Pak J Med Sci. 2016 Jul-Aug.

Abstract

Objective: We aimed to evaluate the relationship between IL-6-174G>C, -572G>C and -597G>A polymorphisms and development of coronary artery diseases in a Chinese population.

Methods: A total of 275 patients with coronary artery disease and 296 healthy control subjects were collected between January 2013 and November 2014. The IL-6 genotyping for -174G>C, -592G>C and -597G>A polymorphic sites was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) according to the manufacturer instructions.

Results: Using unconditional regression analysis, we observed that the AC and CC genotypes of IL-6 -592A>C were associated with the increased risk of developing coronary artery disease when compared with the AA genotype, and the adjusted ORs (95%CI) were 1.63(1.12-2.38) and 2.70(1.57-4.67), respectively. Additionally, the C allele of IL-6 -592A>C (OR=1.65, 95%CI=1.29-2.11) was correlated with a higher risk of developing coronary artery disease in comparison to the A allele. However, no relationship was found between IL-6-174G>C and -597G>A polymorphisms and coronary artery disease susceptibility.

Conclusion: This study suggests that IL-6 -592G>C polymorphism is correlated with the risk of coronary artery disease. More well-designed prospective studies based on large sample size, multiple SNPs or haplotypes are required to confirm the current findings.

Keywords: -174G>C; -572G>C; -597G>A; Coronary artery disease; Interleukin-6; Polymorphism.

PubMed Disclaimer

References

    1. Cheng TO. Rising incidence of coronary artery disease in China in parallel with rising ’normal’ plasma cholesterol levels. Atherosclerosis. 2004;173(2):371. - PubMed
    1. Zidi W, Allal-Elasmi M, Zayani Y, Zaroui A, Guizani I, Feki M, et al. Metabolic Syndrome, Independent Predictor for Coronary Artery Disease. Clin Lab. 2015;61(10):1545–1552. - PubMed
    1. Duval S, Long KH, Roy SS, Oldenburg NC, Harr K, Fee RM, et al. The Contribution of Tobacco Use to High Health Care Utilization and Medical Costs in Peripheral Artery Disease: A State-Based Cohort Analysis. J Am Coll Cardiol. 2015;66(14):1566–1574. - PubMed
    1. Xuan Y, Wang LN, Wei PM, Zhi H, Lu ZH. B-cell lymphoma 2 rs17757541 C>G polymorphism was associated with an increased risk of coronary artery disease in a Chinese population. Int J Clin Exp Pathol. 2015;8(11):15147–15154. - PMC - PubMed
    1. Wang BJ, Liu J, Geng J, Zhang Q, Hu TT, Xu B. Association between three interleukin-10 gene polymorphisms and coronary artery disease risk: a meta-analysis. Int J Clin Exp Med. 2015;8(10):17842–1755. - PMC - PubMed

LinkOut - more resources