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. 2016 Aug 16;3(1):e000106.
doi: 10.1136/bmjgast-2016-000106. eCollection 2016.

Assessment of health utilities and quality of life in patients with non-alcoholic fatty liver disease

Mehmet Sayiner  1 , Maria Stepanova  2 , Huong Pham  1 , Bashir Noor  1 , Mercedes Walters  2 , Zobair M Younossi  3
Affiliations

Assessment of health utilities and quality of life in patients with non-alcoholic fatty liver disease

Mehmet Sayiner et al. BMJ Open Gastroenterol. .

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease associated with increased liver-related mortality. Additionally, NAFLD could potentially impair health-related quality of life. Although an approved treatment for NAFLD does not exist, a number of new drugs for treatment of NAFLD are being developed. As the efficacy and safety of these regimens are being established, their cost-effectiveness, which requires the use of quality of life metrics and health utility scores to quality-adjusted outcomes, must also be assessed. The aim of this study was to report quality of life and health utilities in patients with NAFLD with and without cirrhosis for future use.

Methods: Patients with NAFLD were seen in an outpatient clinic setting. Each patient had extensive clinical data and completed the Short Form-36 (SF-36 V.1) questionnaire. The SF-6D health utility scores were calculated.

Results: There were 89 patients with the spectrum of NAFLD completed the SF-36 questionnaire: 59 with non-cirrhotic NAFLD and 30 with cirrhosis. Patients with NAFLD had significantly lower quality of life and health utility scores than the general population (all p<0.0001). Furthermore, patients with cirrhosis had lower quality of life and utility scores than non-cirrhotic NAFLD patients: SF-6D 0.660±0.107 in non-cirrhotic NAFLD vs 0.551±0.138 in cirrhotic NAFLD (p=0.0003).

Conclusions: Health utilities and quality of life scores are impaired in patients with cirrhotic NAFLD. These values should be used in cost-effectiveness analysis of the upcoming treatment regimens for advanced NAFLD.

Keywords: CIRRHOSIS; FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS; QUALITY OF LIFE.

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Figures

Figure 1
Figure 1
The SF-36 HRQL scores and SF-6D health utilities in patients with cirrhotic and non-cirrhotic NAFLD. Note: The summary scores and the utility scores were transformed to a 0–100 scale for the purpose of presentation. All p<0.05, except for MH. HRQL, health-related quality of life; MH, mental health; NAFLD, non-alcoholic fatty liver disease; SF-36, Short Form-36.
See this image and copyright information in PMC

References

    1. Fazel Y, Koenig AB, Sayiner M, et al. . Epidemiology and natural history of non-alcoholic fatty liver disease. Metabolism 2016;65:1017–25. doi:10.1016/j.metabol.2016.01.012 - DOI - PubMed
    1. Golabi P, Sayiner M, Fazel Y, et al. . Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis. Expert Rev Gastroenterol Hepatol 2015;10:63–71. doi:10.1586/17474124.2016.1099433 - DOI - PubMed
    1. Chalasani N, Younossi Z, Lavine JE, et al. . The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 2012;55:2005–23. doi:10.1002/hep.25762 - DOI - PubMed
    1. Younossi ZM, Koenig AB, Abdelatif D, et al. . Global epidemiology of non-alcoholic fatty liver disease—meta-analytic assessment of prevalence, incidence and outcomes. Hepatology 2016;64: 73–84. doi:10.1002/hep.28431 - DOI - PubMed
    1. Golabi P, Otgonsuren M, Cable R, et al. . Non-alcoholic fatty liver disease (NAFLD) is associated with impairment of health-related quality of life (HRQOL). Health Qual Life Outcomes 2016;14:18 doi:10.1186/s12955-016-0420-z - DOI - PMC - PubMed