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. 2016 Jul;2(4):412-428.
doi: 10.1016/j.jcmgh.2016.04.003.

Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals

Michael Camilleri  1 , David R Linden  2
Affiliations

Measurement of Gastrointestinal and Colonic Motor Functions in Humans and Animals

Michael Camilleri et al. Cell Mol Gastroenterol Hepatol. 2016 Jul.

Abstract

Accurately measuring the complex motor behaviors of the gastrointestinal tract has tremendous value for the understanding, diagnosis and treatment of digestive diseases. This review synthesizes the literature regarding current tests that are used in both humans and animals. There remains further opportunity to enhance such tests, especially when such tests are able to provide value in both the preclinical and the clinical settings.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Examples of the wide range of motility measurements available for human studies: stable isotope breath test, scintigraphic transit, intraluminal manometry by perfused manometers or strain gauges on tubes or wireless capsules, and measurement of gastric capacity and accommodation by SPECT or high-resolution manometry.
Figure 2
Figure 2
Antroduodenal motility tracings in the postprandial period with sensors 1-cm apart. Note in the upper example the consistent phasic and tonic contractions at the pylorus with intermittent loss of distal antral contractions 1 and 2 cm proximal to the pylorus. In contrast, note the consistent antropyloric coordination in the normal example in the lower tracings.
Figure 3
Figure 3
Colonic compliance in (A) healthy, (B) functional constipation/constipation-predominant irritable bowel syndrome, (C) diarrhea-predominant irritable bowel syndrome (IBS-D) groups; and (D) patients with chronic megacolon. Note the markedly increased volume of the intracolonic balloon (10-cm long) in patients with megacolon compared with controls.
See this image and copyright information in PMC

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