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. 1989 Jun 1;260(2):601-4.
doi: 10.1042/bj2600601.

The Streptomyces K15 DD-peptidase/penicillin-binding protein. Active site and sequence of the N-terminal region

M Leyh-Bouille  1 , J Van Beeumen, S Renier-Pirlot, B Joris, M Nguyen-Distèche, J M Ghuysen
Affiliations

The Streptomyces K15 DD-peptidase/penicillin-binding protein. Active site and sequence of the N-terminal region

M Leyh-Bouille et al. Biochem J. .

Abstract

The N-terminal region of the Streptomyces K15 DD-peptidase/penicillin-binding protein shows high homology with that of other penicillin-interactive proteins or domains. The active-site serine residue of the conserved tetrad Ser-Xaa-Xaa-Lys occurs at position 35. There is no indication for the presence of a signal peptide or an N-terminal hydrophobic sequence, suggesting that the Streptomyces K15 enzyme is probably anchored to the membrane by a C-terminal peptide segment.

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