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. 2017 May;19(5):510-518.
doi: 10.1080/10286020.2016.1232253. Epub 2016 Sep 21.

Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation

Hoang Le Tuan Anh  1 , Do Thanh Tuan  2 , Do Thi Trang  1 , Bui Huu Tai  1 , Nguyen Xuan Nhiem  1 , Pham Hai Yen  1 , Phan Van Kiem  1 , Chau Van Minh  1 , Tran Minh Duc  3 , Hee Kyoung Kang  4 , Youn Chul Kim  5 , Young Ho Kim  6
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Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation

Hoang Le Tuan Anh et al. J Asian Nat Prod Res. 2017 May.

Abstract

Inhibitory effects of NO production in RAW 264.7 macrophages guided the isolation of nine prenylated isoflavones, including a new cudraisoflavone L (1) and eight known metabolites furowanin B (2), erysubin A (3), wighteone (4), lupalbigenin (5), laburnetin (6), isolupalbigenin (7), 6,8-diprenylorobol (8), millewanin H (9) from the leaves of Cudrania tricuspidata. At the concentration of 10 μM, compounds 1, 2, and 4 significantly inhibited NO production with the inhibitory values of 72.5 ± 2.4, 66.9 ± 1.8, and 55.4 ± 2.7%, respectively. In addition, all of isolated compounds 1-9 showed promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 μM).

Keywords: Cudrania tricuspidata; NO inhibitor; Prenylated isoflavone; anti-leukemia; cudraisoflavone L.

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