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Review
. 2017 Jan;81(1):63-72.
doi: 10.1080/09168451.2016.1222266. Epub 2016 Sep 21.

Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation

Masahito Suiko  1 , Katsuhisa Kurogi  1   2 , Takuyu Hashiguchi  1 , Yoichi Sakakibara  1 , Ming-Cheh Liu  2
Affiliations
Review

Updated perspectives on the cytosolic sulfotransferases (SULTs) and SULT-mediated sulfation

Masahito Suiko et al. Biosci Biotechnol Biochem. 2017 Jan.

Abstract

The cytosolic sulfotransferases (SULTs) are Phase II detoxifying enzymes that mediate the sulfate conjugation of numerous xenobiotic molecules. While the research on the SULTs has lagged behind the research on Phase I cytochrome P-450 enzymes and other Phase II conjugating enzymes, it has gained more momentum in recent years. This review aims to summarize information obtained in several fronts of the research on the SULTs, including the range of the SULTs in different life forms, concerted actions of the SULTs and other Phase II enzymes, insights into the structure-function relationships of the SULTs, regulation of SULT expression and activity, developmental expression of SULTs, as well as the use of a zebrafish model for studying the developmental pharmacology/toxicology.

Keywords: 3′-phosphoadenosine-5′-phosphosulfate; Phase II; detoxifying enzymes; sulfotransferase.

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Figures

None
Graphical abstract
Fig. 1.
Fig. 1.
Typical SULT-mediated sulfation reactions.
Fig. 2.
Fig. 2.
Classification of the human and mouse SULTs based on their amino acid sequences.
Fig. 3.
Fig. 3.
Developmental stage-dependent expression of representative zebrafish SULTs.
See this image and copyright information in PMC

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