Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2016 Aug;5(4):446-9.
doi: 10.21037/tlcr.2016.07.06.

Afatinib in lung cancer harboring EGFR mutation in the LUX-Lung trials: six plus three is greater than seven?

Tetsuya Mitsudomi  1 , Yoshihisa Kobayashi  1
Affiliations
Comment

Afatinib in lung cancer harboring EGFR mutation in the LUX-Lung trials: six plus three is greater than seven?

Tetsuya Mitsudomi et al. Transl Lung Cancer Res. 2016 Aug.
No abstract available

PubMed Disclaimer

Conflict of interest statement

T Mitsudomi received honoraria from Boehringer-Ingelheim, AstraZeneca, Chugai and research fund from Boehringer-Ingelheim and Chugai. Y Kobayashi has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Progression free survival and overall survival in trials comparing chemotherapy with the first-generation EGFR-TKIs (A) (2-8) and LUX-Lung trials (B) (9-12). EGFR-TKIs, epidermal growth factor receptor-tyrosine kinase inhibitors.
See this image and copyright information in PMC

Comment on

References

    1. Mitsudomi T, Yatabe Y. Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer. Cancer Sci 2007;98:1817-24. 10.1111/j.1349-7006.2007.00607.x - DOI - PMC - PubMed
    1. Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362:2380-8. 10.1056/NEJMoa0909530 - DOI - PubMed
    1. Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010;11:121-8. 10.1016/S1470-2045(09)70364-X - DOI - PubMed
    1. Zhou C, Wu YL, Chen G, et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 2011;12:735-42. 10.1016/S1470-2045(11)70184-X - DOI - PubMed
    1. Rosell R, Carcereny E, Gervais R, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 2012;13:239-46. 10.1016/S1470-2045(11)70393-X - DOI - PubMed