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Comment
. 2017 Feb 1;38(5):373-375.
doi: 10.1093/eurheartj/ehw386.

Unravelling the molecular basis for cardiac iron metabolism and deficiency in heart failure

Pavel Zhabyeyev  1 , Gavin Y Oudit  1
Affiliations
Comment

Unravelling the molecular basis for cardiac iron metabolism and deficiency in heart failure

Pavel Zhabyeyev et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
Relationship between myocardial iron homeostasis and the development of heart failure. (A) Cellular homeostasis of iron and ATP production in normal, IRP1/2-deficent, and IRP1/2-deficient with iron-supplemented cardiomyocytes. (B) Link between IRP1/2 deficiency, iron homeostasis, ATP production, and heart failure. (C) Therapeutic strategies aimed at improving myocardial iron levels and clinical outcomes in patients with heart failure. IRP1/2, iron response protein 1 and 2; Trf1, transferrin receptor 1; Fpn, ferroportin; DMT1, divalent metal transporter 1; ACEi, angiotensin-converting enzyme inhibitor; MRA, mineralocorticoid receptor antagonist.
See this image and copyright information in PMC

Comment on

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