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. 1989 Aug 1;34(1-2):111-6.
doi: 10.1016/s0166-4328(89)80094-4.

Evidence that apomorphine and (+)-amphetamine produce different types of circling in rats

A R Cools  1 , W Scheenen, D Eilam, I Golani
Affiliations

Evidence that apomorphine and (+)-amphetamine produce different types of circling in rats

A R Cools et al. Behav Brain Res. .

Abstract

Apomorphine and (+)-amphetamine are known to produce circling in naive rats. Frame by frame analysis of videotape recordings of the behaviour of Wistar rats treated with a subcutaneous injection of apomorphine (1.1 mg/kg; n = 8) or (+)-amphetamine (0.5 and 1.0 mg/kg; n = 8 and n = 8) was used to study this behaviour in more detail. In line with previously reported studies, apomorphine was found to change the functioning of hindlimb stepping. In contrast, (+)-amphetamine was found to change the functioning of forelimb stepping. These data imply that apomorphine and (+)-amphetamine produce their drug-specific circling via different substrates within the brain.

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